It improves muscle insulin resistance through the LKB1/AMPK pathway, downregulates liver gluconeogenesis genes, and stimulates SIRT1 (Sirtuin 1) (Picard and Auwerx, 2002; Kim et al., 2009; Na et al., 2011; Yang et al., 2013; Jiménez-Flores et al., 2014). The gene discussed is PRKAA1; the disease is Insulin resistance.