It improves muscle insulin resistance through the LKB1/AMPK pathway, downregulates liver gluconeogenesis genes, and stimulates SIRT1 (Sirtuin 1) (Picard and Auwerx, 2002; Kim et al., 2009; Na et al., 2011; Yang et al., 2013; Jiménez-Flores et al., 2014). This evidence concerns the gene SIRT1 and Insulin resistance.