Through the convergence of the SVM-RFE approach and LASSO regression, eight important genes were found to be discriminative characteristics that might be used to separate asthma sufferers from healthy individuals [LOC100132287, carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5); proline-rich 4 (PRR4); carboxypeptidase A3 (CPA3); periostin (POSTN); LY6/PLAUR domain cintaining 2 (LYPD2); transcobalamin 1 (TCN1); and secretoglobin family 3A member 1 (SCGB3A1)], as shown in the Venn diagram (Figures 1C–E). The gene discussed is POSTN; the disease is asthma.