There is an inverse correlation between VDR expression and malignancy as has been reported in some studies.20,21 While our study indicated that high VDR expression is positively correlated with adverse PCa features, Hendrickson et al demonstrated that high VDR expression had significant association with low PSA at diagnosis, low Gleason score, and less advanced tumor stage.21 It is interesting to note that vitamin D has shown antiproliferative activity in PCa. The gene discussed is VDR; the disease is posterior cortical atrophy.