VDR and cancer: For example, some polymorphic variants of VDR such as BsmI and ApaI are associated with poor prognostic factors and are predictive of lethal cancer.25 The report by Beckett et al showed that in the presence of BsmI, high UV exposure would lead to increased methylation density of the VDR, leading to dysregulation of the antiproliferative activity of the vitamin D/VDR system.26,27 Doig et al10 also showed that there can be selective attenuation of response of VDR to the antiproliferative effect of binding to vitamin D through transcriptional reprogramming.