Notably, ASCL1 expression was inversely associated with CXCL10 and CCL20, consistent with previous research (13), which showed that ASCL1 downregulates these chemokines, impairing immune cell migration and contributing to an “immune desert” phenotype, thus compromising immune responses in cancers such as lung adenocarcinoma (13). This evidence concerns the gene CXCL10 and lung adenocarcinoma.