As the infection progresses, macrophages migrate into the lung interstitium where they recruit other innate cells such as neutrophils, monocytes, macrophages, and dendritic cells due to the release of cytokines, including TNF-α, IL-1α, IL-6, IL-1β and IFN-γ, thus favouring the dissemination of mycobacteria to uninfected cells. The gene discussed is TNF; the disease is infection.