IFNG and Mendelian susceptibility to mycobacterial diseases: MSMD involves specific mutations in 18 genes (IFNG, IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, IL12RB2, IL23R, RORC, TBX21, IRF8, SPPL2A, ISG15, TYK2, JAK1, ZNFX1, NEMO, CYBB), which are associated with an impaired IFNγ/IL-12 response/production (35).