To test whether CD147 mediates SARS-CoV-2 uptake into monocytes by recognizing its binding partners CypA and CypB incorporated in SARS-CoV-2 virions, we pretreated isolated monocytes with two mAbs targeting the CD147 IgII domain (MEM-M6/6 and MEM-M6/7), or with an isotype control mAb, followed by infection with SARS-CoV-2. Here, PPIA is linked to infection.