CDKN1A and cancer: In human dental pulp stem cells (DPSCs), METTL3/METTL14 have been shown to catalyze m6A modification in the 3’UTR of CDKN1A mRNA, which encodes the cell cycle-dependent kinase inhibitor p21, thereby promoting cell cycle arrest in oxidative stress-induced senescence of human cancer cells (234, 235).