In the study conducted by Barrette et al., the effects of VP on tumor proliferation and migration in vitro were assessed using glioblastoma patient-derived cell lines, as well as its impact on tumor burden and survival rates in patient-derived xenograft (PDX) models (93).This study demonstrates that VP can disrupt the migration and epithelial-mesenchymal transition (EMT) of GBM by inhibiting YAP-TEAD activity. The gene discussed is YAP1; the disease is glioblastoma.