have demonstrated that the Suppressor of Cytokine Signaling 1 (SOCS1) (86), Suppressor of Cytokine Signaling 6 (SOCS6) (87), and Phosphatase and Tensin Homolog (PTEN) (88) are implicated in various human malignant tumors, including NSCLC. The gene discussed is SOCS1; the disease is non-small cell lung carcinoma.