The results suggested that, among various factors interacting with each other, the preoperative P-CRP levels (>8.36, ≤8.36), number of tumors (single, multiple), tumor size (≤3cm, >3cm), tumor staging (PTa, PT1), and pathological grading (G1, G2, G3) of NMIBC patients were significantly associated with RFS (P < 0.05), and all were independent factors affecting the RFS after TURBT for NMIBC patients. Here, CRP is linked to neoplasm.