Moreover, several PD-associated genes, such as PINK1, Parkin, DJ-1/PARK7, the Leucine-rich repeat kinase2 (LRRK2), the Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2), VPS35 and the tumor necrosis factor receptor associated protein 1 (TRAP1), have been shown to be involved in OXPHOS regulation [88] (Table 2). Here, PRKN is linked to Parkinson disease.