Our data showed that in addition to augmenting ADCC, CD64-CR-dependent cytotoxicity boosted the synthesis of IFNγ, which in turn specifically induced the upregulation or de novo expression of key immunoregulatory cell surface molecules, including PD-L1, in CRC and SCCHN cells and HLA-DR preferentially in FaDu cells but also in subsets of SCCHN and CRC cells. This evidence concerns the gene FCGR1A and head and neck squamous cell carcinoma.