AZIN1 and neoplasm: Moreover, while AZIN1 regulation of polyamine synthesis is a general mechanism that can be implicated in many pathways relevant to tumorigenesis (and recognizing that other mechanisms, such as RNA modification, may also contribute to AZIN1-related tumor development), our discovery of a direct, specific c-Myc/AZIN1 negative feedback loop is a novel finding that provides an mechanistic insight with potential therapeutic implications [69].