In conjunction with the high‐throughput GEO database, we analysed the DEGs in the muscles (GSE209528, GSE175562, and GSE213148) of non‐osteoporosis and osteoporosis mice, DEGs in non‐osteoporosis and osteoporosis mouse bones (GSE186104 and GSE202395), and selected the intersection to screen the middle two candidate genes (keratocan and Syn2; Figure 1A). Here, SYN2 is linked to osteoporosis.