In light of accumulating evidence that HH/GLI signaling regulates the induction of immunosuppressive mechanisms [16, 17], we interrogated our HH/GLI and proinflammatory IL6/STAT3 mRNA profiling data [41] for novel synergistically regulated HH-IL6 target genes with a known function in immunosuppression and cancer immune evasion. This evidence concerns the gene STAT3 and cancer.