CXCL8 and early-onset autosomal dominant Alzheimer disease: Moreover, several studies in animal models with Alzheimer's disease have shown that higher IL8 content promotes smaller volumes of GM in the hippocampus of monkeys, as well as brain tissue damage in rodents, through neurotoxic action by augmenting the transendothelial migration of neutrophils, increasing the release of reactive oxygen species (ROS) and the production of neutrophil‐mediated proteases [33], S37.