Furthermore, malic enzyme 1 (ME1) was significantly up‐regulated in MASLD patients which catalyses the conversion of malate to pyruvate and generates NADPH, and pyruvate is transported into mitochondria via MPC1 and MPC2 which were up‐regulated in patients with increased FGF21 expression. The gene discussed is ME1; the disease is metabolic dysfunction-associated steatotic liver disease.