Specifically, we found a low positive correlation between APLN and CYR61 (r = 0.16), a stronger correlation between APLNR and CYR61 (r = 0.68), a low correlation between APLNR and RIC8A (r = 0.20), and a moderate correlation between APLNR and TUBA1A (r = 0.58) in tumor patients (Fig. 2N). Here, CCN1 is linked to neoplasm.