In contrast, ATP-dependent RNA helicase (DHX36), Synembryn-A (Ric8a), Protein CYR61 (Cyr61), Tubulin alpha-1A (Tuba1a), and probable 28S rRNA (cytosine-C(5))-methyltransferase (NSUN5), which are associated with poor prognosis in colon cancer, are upregulated in APLN-expressing cells and downregulated in APLN-DM-expressing cells. Here, APLN is linked to colonic neoplasm.