Hypoxia is a common feature of the microenvironment in almost all solid tumors and is frequently associated with angiogenesis and cancer growth, including CRC and has been reported to induce APLN expression in endothelial cells (Andersen et al, 2011) and Furin during regenerative angiogenesis (Khatib et al, 2016). This evidence concerns the gene APLN and colorectal carcinoma.