Apelin-dm also attenuated tumor growth (Fig. 5O,P) and angiogenesis (Fig. 5O,Q) induced by cancer cells in the CAM assay, and reduced tumor blood flow in mice with subcutaneous HCT116 colon cancer tumors (Fig. 5R,S) and other cancer cell types (MDA-MB-231) (Fig. 5T). This evidence concerns the gene APLN and colonic neoplasm.