IgE also plays a relevant role in different autoimmune diseases, including organ-specific diseases such as bullous pemphigoid, Grave’s disease, Hashimoto disease, and autoimmune uveitis, as well as in systemic diseases such as systemic lupus erythematosus (SLE), mixed connective tissue disease, Gougerot-Sjögren syndrome, and systemic sclerosis [298]. Here, IGHE is linked to systemic lupus erythematosus.