Two hypotheses support the potential antitumor effects of IgE: i) the immune surveillance hypothesis, which considers atopy as a condition associated with chronic enhanced immune responses able to detect and eliminate potential altered precancerous cells [310]; and ii) the prophylaxis hypothesis, which suggests that the typical clinical signs and symptoms of allergic diseases (i.e., coughing, sneezing, mucus production or itching) help to expel potential carcinogens and to enhance tissue repair [311, 312]. This evidence concerns the gene IGHE and allergic disease.