In SLE, specific IgE antibodies bind to dsDNA, generating immunocomplexes that are recognized and internalized into endosomal compartments by plasmacytoid dendritic cells (pDCs) through the high-affinity IgE FcεRI, which leads to TLR9-mediated potent interferon and proinflammatory responses, contributing to self-destructive autoimmunity [305]. Here, IGHE is linked to systemic lupus erythematosus.