IGHE and cancer: On the other hand, two hypotheses support the potential protumor effects of IgE: iii) the chronic inflammation hypothesis, which suggests that IgE-mediated allergic inflammation is associated with oxidative stress, gene mutations and tissue remodeling, thus increasing cancer risk [310]; and iv) the Th2 skewing hypothesis, which suggests that enhanced Th2 responses impair antitumor Th1 immune responses, thus promoting local tissue environments that are permissive for cancer development [299].