Together with the significant immune shift to Th2 cell abundance in AD patients, Th2-specific DCs display signatures associated with skin-homing factors (ITGA4, ITGB1, and C-C chemokine receptor (CCR) 2), with low CD103 (ITGAE) and high CD11c (ITGAX) levels [67]. Here, ITGAX is linked to Alzheimer disease.