Neutropenia is one of the symptoms of Wolcott-Rallison syndrome caused by mutations in PERK, encoded by the EIF2AK3 gene (Lundgren et al, 2019), and heightened ER stress was reported in neutropenias caused by mutations in ELANE and glucose-6-phosphate subunit α gene (G6PC3) (Boztug et al, 2009; Nanua et al, 2011; Sapra et al, 2020). Here, G6PC3 is linked to Decreased total neutrophil count.