Other notable pathways include nitrogen metabolism, HIF-1 signaling, gastric acid secretion, proximal tubule bicarbonate reclamation, PD-L1 expression and PD-1 checkpoint regulation in cancer, NOD-like receptor signaling, legionellosis, calcium signaling, Kaposi sarcoma-associated herpesvirus infection, antifolate resistance, steroid hormone biosynthesis, pancreatic secretion, propanoate metabolism, and inflammatory bowel disease. Here, CD274 is linked to inflammatory bowel disease.