In terms of initial presentation, the only difference found between PARK-LRRK2, PARK-SNCA, and PARK-VPS35 was that the most common sign and symptom in both PARK-SNCA (31.2%) and PARK-VPS35 patients (15.9%) was bradykinesia, while in LRRK2 variant carriers, it was tremor (52.5%). Here, VPS35 is linked to Bradykinesia.