It appears that C-1 mitigates the increase in aorta thickening of obese rats by affecting insulin resistance, adipokines hormones (leptin, adiponectin, resistin) and MCP-1,a chemokine Our results indicate that the treatment of obese rats with C-1 reduced insulin resistance which can contribute to endothelial dysfunction and atherosclerosis via induction of hyperglycemia along with dyslipidemia that causes OS and inflammatory response58. Here, RETN is linked to endothelial dysfunction.