Obesity is linked with low-grade inflammation that is considered a vital risk factor for developing CVDs and metabolic syndrome via increased inflammatory mediators such as IL6 , CRP and TNF\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α , followed by vascular and endothelial dysfunction68. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.