SYK and systemic lupus erythematosus: Due to the Syk inh impact against pro-inflammatory responses and ETs formation of LPS + WGP-activated macrophages and neutrophils (Figs. 3, 4), Syk inh was further tested in mice using 4-wk-oral administration of Syk inh in 40-wk-old FcγRIIb−/− mice, a symptomatic lupus model, as indicated by positive anti-dsDNA with proteinuria, leaky gut (FITC-dextran assay), endotoxemia, and glucanemia (Supplementary Fig. 1).