FCGR2B and systemic lupus erythematosus: One of the situations during active lupus is the translocation of microbial molecules from the gut (LPS and BG) to the bloodstream, referred to as leaky gut or gut leakage, as demonstrated in symptomatic FcγRIIb−/− mice and some patients [10], that provokes immune cells and enhances cell death (apoptosis), resulting in cell death-induced auto-antigen presentation, increased autoantibody production, elevated circulating immune complexes (CIC) deposition, and, finally, lupus disease exacerbation [10, 11].