CST3 and pancreatitis: The disease severity marker serum amylase was higher 1 h and 24 h after induction of pancreatitis in Cst3−/− mice (Fig. 7B), and intrapancreatic trypsinogen activation was increased 1, 8 and 24 h after the onset of pancreatitis (Fig. 7C), while the activity of chymotrypsin was elevated at 1 h and 8 h (Fig. 7D).