While PD-1 expression in T cells (CD4+ and CD8 + ) resulted unchanged (Supplementary Figure 3), I2-treated tumors revealed a reduced expression of PD-L1 in the monocytic myeloid-derived suppressor cell (M-MDSC) subset monocytes and in tumor-associated macrophages (TAM) (Fig. 7M and Figure Supplementary 4). The gene discussed is CD4; the disease is neoplasm.