GPT and liver disorder: The current HBV treatment guidelines from WHO, the American Association for the Study of Liver Diseases (AASLD), the European Association for the Study of the Liver (EASL), and the Asian-Pacific Association for the Study of the Liver (APASL) are summarized in Table 1.[13–16] In general, HBV DNA levels of 2000 IU/ml or 20,000 IU/ml are used as cut-offs for treatment, depending on alanine aminotransferase (ALT) and other clinical parameters.