These cytokines, coupled with the decrease of natural killer cells, selective depletion of T lymphocytes (CD3+) and the CD8 + cytotoxic T cell subset specifically, suggests the critical role of components of innate and adaptive cellular control of active or recent viral infection.[2,4,6,7,31,32] The absence of these changes in KD seems to indicate an alternative or less recent infectious etiology.[33,34]. The gene discussed is CD8A; the disease is viral infectious disease.