Most studies compare and stratify inflammatory markers for severity between severe acute COVID-19 and MIS-C or between MIS-C and KD and less so for stratification of severity of MIS-C itself.[2,4,13,26,27] In our study, children satisfying our definition of more severe MIS-C had higher CRP, NT-pro BNP, and lower lymphocytes, when compared with children with less severe MIS-C. This evidence concerns the gene NPPB and COVID-19.