In pan-cancer, PTPRC, CD86, TYROBP, CD8A, ITGB2, FCGR3A were also highly correlated with active CD8 + T cells (Act CD8) (Fig. 5, Figure S3A–S3D, Supplemental Digital Content, http://links.lww.com/MD/O352). This evidence concerns the gene ITGB2 and cancer.