CD8A and cancer: In oral squamous cell carcinoma, ITGB2 was highly expressed in cancer associated fibroblasts (CAFs) compared to normal fibroblasts, and the up-regulation of ITGB2 in CAFs was associated with more Ki67 + tumor cells, which suggested that ITGB2 could promote the proliferation of oral squamous cell carcinoma.[32] We found that ITGB2 expression was positively correlated with CD8 + T cells in SCLC.