However, it is worth noting that AA is a noninvasive operation of external treatment of traditional Chinese medicine, with high safety.[41] As is reported previously, AA can relieve neuronal excitability through facilitating the normalization of pathological hypersensitive reflex pathways connecting the ear microsystem and somatotopic brain, and regulating proinflammatory cytokines, such as IL-1b, IL-6, and TNF.[42] This study confirms that AA is effective in treating insomnia in breast cancer patients. This evidence concerns the gene TNF and breast cancer.