LAYN and systemic lupus erythematosus: Using 0.8 as a critical threshold for posterior probability, the 4 proteins identified by MR (ICAM-1, FCG2B, N-terminal pro-BNP, Layilin) may share the same SLE variant.[42] Two of the 4 identified proteins (ICAM-1 and FCG2B) were found to be associated with other traits by phenotypic scanning, but none of the associations fully explained the relationship between the identified proteins and SLE.