The PPI network (Fig. S3, Supplemental Digital Content, http://links.lww.com/MD/O356) revealed interactions between 3 prioritized proteins (FCG2B, ICAM-1, N-terminal pro-BNP) and current SLE drugs targets (Table S5, Supplemental Digital Content, http://links.lww.com/MD/O357, Fig. 6). This evidence concerns the gene ICAM1 and systemic lupus erythematosus.