SORL1 and major depressive disorder: More present among the small molecules most correlating and/or anti-correlating with the sorl1 fingerprint were drugs used to treat depression (Figure 5—figure supplement 1a, simulated p-value = 0.049), targeting the serotonin transporter SLC6A4 (Figure 5a and b, simulated p-value = 0.015), and affecting the ‘serotonergic synapse’ pathway (Figure 5—figure supplement 1b, simulated p-value = 0.027).