The top variant at the SORL1 locus was within an intron of SORL1 (Schwartzentruber et al., 2021), but rare protein-coding variants in SORL1 were likely causal for some early-onset AD patients through haploinsufficiency or deleterious effects on protein function (Nicolas et al., 2016; Pottier et al., 2012; Thonberg et al., 2017). Here, SORL1 is linked to Alzheimer disease.