CD4 and neoplasm: Therelease of tumor cell debris and apoptotic bodies/necrosisfragments has the potential to elicit the so-called immunogenic celldeath (ICD),12 a mechanism that activatesdamage-associated molecular patterns (DAMPs),13 leading to dendritic cell maturation and migration to lymph nodes.Here, they present tumor antigens to CD4+ and CD8+ T cells, which in turn are activated and redirected to systemiccirculation to finally infiltrate the tumor mass.14