IGFBP7 and lung carcinoma: Additionally, in specific cases a relatively high change in Young’s modulus did not correspond to marked expression changes of a given gene — see for example low CAV1 changes observed in MCF10A PIK3CA mutant (Figure 4—figure supplement 4A), or low IGFBP7 changes in intestine and lung carcinoma samples (Figure 4—figure supplement 4C).