Additionally, in specific cases a relatively high change in Young’s modulus did not correspond to marked expression changes of a given gene — see for example low CAV1 changes observed in MCF10A PIK3CA mutant (Figure 4—figure supplement 4A), or low IGFBP7 changes in intestine and lung carcinoma samples (Figure 4—figure supplement 4C). This evidence concerns the gene PIK3CA and lung carcinoma.