MAPT and Alzheimer disease: These aptamers can target tau isoforms and phosphorylationsites with nanomolar sensitivity, making them valuable tools for detectingtau in biofluids, studying tauopathy mechanisms, and potentially servingas therapeutic agents to mitigate AD associated with tau protein aggregation.9,17 Aptamer-based sensors (aptasensors) have several advantages overantibody-based biosensors.