YTHDF1 fosters intestinal injury, tumor growth, and metastasis by boosting ARHGEF2 translation and CXCL1/CXCR2 activation via NF-κB p65, hindering T-cell infiltration and aiding CRC progression.69–71 This process is also closely related to the activation of the Wnt/β-catenin pathway.72 In contrast, the mechanism of action of YTHDF2 is more complex. The gene discussed is NFKB1; the disease is neoplasm.