ALKBH5 and colonic neoplasm: However, ALKBH5 overexpression inhibits colon cancer and CRC cell proliferation, migration, and invasion.65 Mechanistically, ALKBH5 can destabilize PHF20 mRNA by demethylating its 3‘UTR, hindering CRC, and boost CD8 T-cell infiltration in CRC microenvironments by inhibiting NF-κB-CCL5 signaling, mitigating malignancy.66,67 Notably, high-fat diets downregulate FTO and ALKBH5 in CRC patients, reducing Hexokinase 2 (HK2) via m6A-IGF2BP2.