Supplementing with formate can increase the number of CD4IL-17CORγT cells in mice and enhance cancer stem cell (CSCs) stemness through AhR signaling, thereby improving cancer cell invasiveness.109 Similarly, SCFAs produced also induce Th17 cells to affect intestinal immunity.110 H2S and ADP heptose exacerbate the intestinal inflammatory response. The gene discussed is AHR; the disease is cancer.