This, in turn, reduces YTHDF2-mediated degradation of KIF26B mRNA, upregulating KIF26B expression and contributing to F. nucleatum -induced CRC cell invasion and metastasis.183 Butyrate, a metabolic byproduct of intestinal flora, exerts its anti-CRC effects by diminishing m6A levels and suppressing the expression of METTL3 in CRC cells. Here, METTL3 is linked to colorectal carcinoma.