TNNT2 and familial dilated cardiomyopathy: To investigate whether risedronate could correct cardiac contraction of the ΔK210 in vivo, we developed a ΔK210 DCM mouse model using clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9), which led to an expected K210 deletion in TnnT2.