Because of the glucose-dependent mechanism associated with activating GLP-1 receptors, the heightened insulin secretion and suppressed glucagon secretion diminish when fasting glucose levels fall below the normal range, mitigating the potential for hypoglycemia.14 Table offers an overview of various GLP-1 RAs, including details such as their initial dosing and pertinent considerations, including half-lives and renal adjustments.10-21. This evidence concerns the gene INS and Hypoglycemia.