Mutations in SPTB have been implicated in a spectrum of hereditary red blood cell disorders, including HS type 2, hereditary elliptocytosis, and neonatal hemolytic anemia (Llaudet-Planas et al., 2018; Andolfo et al., 2021; Songdej et al., 2024). This evidence concerns the gene SPTB and Congenital hemolytic anemia.