Meta-analyses of systemic inflammatory markers conducted separately in psoriasis (Dowlatshahi et al., 2013) and depression (Köhler et al., 2017; Osimo et al., 2020) show cytokine and acute-phase protein overlap, with serum CRP, IL-6, TNF-α and IL-18 elevation in both disorders. The gene discussed is CRP; the disease is major depressive disorder.