PPARA and Cirrhosis: The drop in both mRNA and protein in hepatic cirrhosis may be due to desensitization of the GPR75 receptor by increased levels of 20-HETE or the conversion of 20-HETE to 20-carboxyl- arachidonic acid (20-COOH-AA) that functions as an activator of PPARα and PPARγ (Fang et al., 2007) that may suppress CYP4A11 and GPR75 gene regulation.