We next examined the Ki67 expression in combined DCIS subtypes whose classification was not dependent on Ki67 (LumB HER2+, HER2-enriched, and TPN) and found statistically significant higher Ki67 expression in “W/invasive” compared to “Pure” subcategories (p-exact = 0.0351, Mann-Whitney test). The gene discussed is ERBB2; the disease is ductal breast carcinoma in situ.