All four TyG indicators and their composite obesity indexes showed nonlinear relationships (P for overall < 0.001, P for nonlinear < 0.05) with CKD and between TyG and CRS, suggesting that TyG and its derived indices may require different analytic approaches when predicting various aspects of cardiorenal disease. This evidence concerns the gene TWIST1 and obesity due to melanocortin 4 receptor deficiency.