We can only speculate, how 2-AG levels are linked to (right) heart failure, but it could be an important signaling mediator, causing the typical biological effects of endocannabinoids at cannabinoid receptor 1, such as reduction in anxiety, analgesia, euphoria and impairment of short-term memory (34–36) and also enhancement of hemorrhagic and endotoxin-induced hypotension (37). The gene discussed is CNR1; the disease is heart failure.