The exposure to WPS in HT mice induced a significant increase in the concentrations of tissue factor, vWF, fibrinogen, and PAI-1 in the plasma compared with HT + air (p  < 0.0001 − p  < 0.01) and NT + WPS (p  < 0.0001 − p  < 0.05) groups (Figure 1). The gene discussed is SERPINE1; the disease is hematocrit.