SNCA and Parkinson disease: We conducted a literature review using PubMed,1 accessing articles published up to 2024 with the search terms “alpha-synuclein,” “exercise,” “sleep,” “synucleinopathy.” Together with a focus on preclinical studies linking α-syn aggregates accumulation and poor sleep quality, and on the possible mechanisms through which physical activity can help counteract α-syn-mediated damage, we reported experimental studies and metanalyses assessing the effects of different forms of physical exercise programs on outcomes associated with sleep quality, particularly in people suffering from PD.