Disruption of NRG1-ErbB4 signaling in the parvalbumin-positive interneurons partially contribute to the isoflurane-induced hippocampus-dependent cognitive impairment in aged mice exposed to isoflurane, which can be reversed by exogenous NRG1-β1 (Li et al., 2014). The gene discussed is PVALB; the disease is Cognitive impairment.