Also, one of the agents with potential hepatoprotective efficacy in the systematic review systematic review and network meta-analysis by Akkahadsee et al.27 is a polyherbal product containing several herbal extracts with unconfirmed interaction profiles.29 Herbal supplements can inhibit cytochrome enzymes, particularly CYP3A4, and potentially reduce RIF levels through metabolic interference, leading to subtherapeutic concentrations and impaired anti-TB efficacy. The gene discussed is CYP3A4; the disease is tuberculosis.