The risk of INH hepatotoxicity increased 7-fold when CYP2E1 c1/c1 was combined with slow-acetylator status.55, 56, 57 However, other reports have come to different conclusions, showing no significant association of CYP2E1 genotype with anti-TB DILI,58,59 thus the role of CYP2E1 polymorphism in INH hepatotoxicity remains controvertible and merits further investigation. Here, CYP2E1 is linked to tuberculosis.