Tumor cells enriched in the AC-like state showed a high expression of SOCS2, although SOCS2 is not a member of the published AC-like signature genes (Figure 2B and C).17 Differential gene expression (DGE) analysis also showed a strong upregulation of SOCS2 in EGFR-amplified TCGA-GBM samples (logarithmic fold change [LFC] = 1.99, false discovery rate [FDR]-adjusted P-value = 1.90e−22). Here, EGFR is linked to glioblastoma.